Synthesis of 2-methyl-5-amino-4-oxo-3-sulfonyl esters as precursors of pseudodipeptides
✍ Scribed by D. Severi; L. Ettouati; J. Paris
- Book ID
- 110550358
- Publisher
- Springer Netherlands
- Year
- 2002
- Tongue
- English
- Weight
- 289 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1573-3149
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## Abstract The synthesis of a series of methyl 3‐amino‐4‐aryl(or methyl)sulfonylthiophene‐2‐carboxylates by reaction of 3‐alkoxy‐2‐aryI(or methyl)sulfonylacrylonitriles with methyl thioglycolate in the presence of triethylamine is described. Hydrolysis/decarboxylation of the ester at the 2‐positio
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## Abstract 2‐Amino‐6‐(3‐methyl‐5‐oxo‐1‐phenyl‐2‐pyrazolin‐4‐yl)‐4‐phenylpyridine‐3‐carbonitrile (1) obtained by the reaction of 4‐(1‐iminoethyl)‐3‐methyl‐1‐phenyl‐2‐pyrazolin‐5‐one with benzylidenemalononitrile, was reacted with triethyl orthoformate followed by hydrazine hydrate, acetic anhydride