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Synthesis of 2-Methyl 16-Membered Macrolide Derived from Tylosin

✍ Scribed by Terui, Yuichi; Kinoshita, Kenji; Kaneda, Yoshie; Akashi, Toshi; Hamaguchi, Takuya; Kawashima, Akira


Book ID
109867714
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
289 KB
Volume
59
Category
Article
ISSN
0021-8820

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Total synthesis of tylonolide, the aglyc
✍ Tatsuyoshi Tanaka; Yuji Oikawa; Tatsuo Hamada; Osamu Yonemitsu πŸ“‚ Article πŸ“… 1986 πŸ› Elsevier Science 🌐 French βš– 286 KB

Segments i (Cll-C17) and ii (Cl-ClO), synthesized from D-glucose by employing some stereoselective reactions and benzyl-type protecting groups, were esterified and cyclized to the 16-membered enone, which was readily converted to tylonolide, the aglycone of tylosin. Tylosin is a typical 16-membered