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Synthesis of 2-imidazolidinylidene propanedinitrile derivatives as stimulators of gastrointestinal motility. 1

✍ Scribed by Sasho, Setsuya; Obase, Hiroyuki; Ichikawa, Shunji; Kitazawa, Takio; Nonaka, Hiromi; Yoshizaki, Rika; Ishii, Akio; Shuto, Katsuichi


Book ID
115501205
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
821 KB
Volume
36
Category
Article
ISSN
0022-2623

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Synthesis of 2-imidazolidinylidene propa
✍ Setsuya Sasho; Hiroyuki Obase; Shunji Ichikawa; Takio Kitazawa; Hiromi Nonaka; R πŸ“‚ Article πŸ“… 1995 πŸ› Elsevier Science 🌐 English βš– 762 KB

Recently, we reported that a ranitidine derivative 2 (fumarate: KW-5092), which had a 2-imidazolidinylidene propanedinitrile moiety (A), showed potent gastrointestinal motility enhancing activity. We have also found that introduction of substituents such as benzyl or 4-fluorobenzyl (i.e., giving 3 o