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Synthesis of 2-fluoronoraristeromycin and its inhibitory activity against Plasmodium falciparum S-Adenosyl-l-homocysteine hydrolase

✍ Scribed by Yukio Kitade; Hiroharu Kojima; Fazila Zulfiqur; Hye-Sook Kim; Yusuke Wataya


Book ID
108073090
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
133 KB
Volume
13
Category
Article
ISSN
0960-894X

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Facile synthesis of 9-[(1β€²R,2β€²S)-2β€²-hydr
✍ Yukio Kitade; Atushi Kozaki; Chizuko Yatome πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 French βš– 75 KB

Treatment of 4%-O-methanesulfonyl-2%,3%-O-isopropylidenenoraristeromycin with KOBu t gave the corresponding 3%,4%dehydro derivative, and subsequent deprotection resulted in the formation of 9-[(1%R,2%S)-2%-hydroxy-3%-oxocyclopentan-1%-yl]-9-Hadenine possessing inhibitory activity against human recom