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Synthesis of 2′-deoxy-2′-fluororibo- and 2′-deoxy-2′,2′-difluororibonucleosides derived from 6-(het)aryl-7-deazapurines

✍ Scribed by Pavla Perlíková; Neus Jornet Martínez; Lenka Slavětínská; Michal Hocek


Book ID
119375638
Publisher
Elsevier Science
Year
2012
Tongue
French
Weight
521 KB
Volume
68
Category
Article
ISSN
0040-4020

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## Abstract Oligonucleotides containing 2′‐deoxyisoguanosine (1) or 2‐chloro‐2′‐deoxyadenosine (2a) have been prepared by solid‐phase synthesis. Suitably protected phosphonates 3a, 4a, and 4b as well as the phosphoramidite of 1 have been obtained from the nucleosides 1, 2a, or 2b __via__ the (dimet