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Synthesis of 2-aryl-2,3-dihydro-4-styrylpyrimidodiazepines in the reaction of 4,5,6-triaminopyrimidine and 2,4,5,6-tetraaminopyrimidine with diarylidenacetones

✍ Scribed by Braulio Insuasty; Henry Insuasty; Jairo Quiroga; Manuel Nogueras; Adolfo Sánchez; M. Dolores López

Publisher
Journal of Heterocyclic Chemistry
Year
1999
Tongue
English
Weight
266 KB
Volume
36
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

New 6‐amino and 6,8‐diamino‐2‐aryl‐2,3‐dihydro‐4‐styryl‐1__H__‐pyrimido[4,5‐b][1,4]diazepines were obtained in the reaction of 2,4,5,6‐tetraaminopyrimidine 1a and 4,5,6‐triaminopyrimidine 1b with one equivalent of the diaryli dene acetones 2 in absolute ethanol with acetic acid as the catalyst. Structure analysis of 6‐amino and 6,8‐diamino‐2‐aryl‐2,3‐dihydro‐4‐styryl‐1__H__‐pyrimido[4,5‐b][1,4]diazepines 3a‐i, determined by detailed nmr measurements, reveals a high regioselectivity of this reaction.

📜 SIMILAR VOLUMES

Reaction of 4,5,6-triaminopyrimidine and
Reaction of 4,5,6-triaminopyrimidine and 2,4,5,6-tetraaminopyrimidine with 3-dimethylaminopropiophenones. Synthesis of new 4-aryl-2,3-dihydropyrimido[4,5-b][1,4]diazepines
✍ Insuasty O. Braulio; Insuasty I. Henry; Quiroga P. Jairo; Claudio Saitz; Carolin 📂 Article 📅 2000 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 192 KB

## Abstract Several new 6‐amino‐ and 6,8‐diamino‐4‐aryl‐2,3‐dihydropyrimido[4,5‐__b__][1,4]diazepines were obtained from the reaction of 4,5,6‐triaminopyrimidine **1a** and 2,4,5,6‐tetraaminopyrimidine **1b** with one equivalent of 3‐dimethylaminopropiophenones **2** in absolute ethanol. Structure

ChemInform Abstract: Reaction of 4,5,6-T
ChemInform Abstract: Reaction of 4,5,6-Triaminopyrimidine and 2,4,5,6-Tetraaminopyrimidine with 3-Dimethylaminopropiophenones. Synthesis of New 4-Aryl-2,3-dihydropyrimido[4,5-b][1,4]diazepines.
✍ Braulio Insuasty O.; Henry Insuasty I.; P. Jairo Quiroga; Claudio Saitz; Carolin 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 28 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

The reaction of 2,4,5,6-tetraaminopyrimi
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✍ Braulio Insuasty; Alfredo Pérez; Diego González; Jairo Quiroga; Herbert Meier 📂 Article 📅 2000 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 142 KB

## Abstract The reaction of the tetraaminopyrimidine 1 with the chalcones **2a‐f** yields, in the presence of catalytic amounts of acetic acid, the 1__H__‐pyrimido[4,5‐__b__][1,4]diazepine derivatives **3a‐f.** The cyclization process consists of a condensation reaction and a Michael type addition.

ChemInform Abstract: The Reaction of 2,4
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✍ Braulio Insuasty; Alfredo Perez; Diego Gonzalez; Jairo Quiroga; Herbert Meier 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 27 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v