Synthesis of 2-amino-6-(2-[18F]fluoro-pyridine-4-ylmethoxy)-9-(octyl-β-d-glucosyl)-purine: a novel radioligand for positron emission tomography studies of the O6-methylguanine-DNA methyltransferase (MGMT) status of tumour tissue

✍ Scribed by Ralf Schirrmacher; Ute Mühlhausen; Björn Wängler; Esther Schirrmacher; Jost Reinhard; Gerd Nagel; Bernd Kaina; Markus Piel; Manfred Wießler; Frank Rösch

• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 86 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)01394-1

✦ Synopsis

The synthesis of the novel glucose conjugated O 6 -methylguanine-DNA methyltransferase (MGMT) inhibitor 2-amino-6-(2-[ 18 F]fluoro-pyridine-4-ylmethoxy)-9-(octyl-a-D-glucosyl)-purine is reported. This compound might serve as a radiotracer for the determination of the MGMT status of tumour tissue.