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Synthesis of 2-Amino-3-hydroxy-4-substituted Pyridines via Regioselective Metalation of 3-(1-Ethylpropyl)[1,3]oxazolo[4,5-b]pyridin-2(3H)-one and Application to Corticotropin Releasing Factor1 Receptor Ligands.

✍ Scribed by Richard A. Hartz; Kausik K. Nanda; Charles L. Ingalls


Publisher
John Wiley and Sons
Year
2005
Weight
25 KB
Volume
36
Category
Article
ISSN
0931-7597

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## Abstract An efficient two‐step synthesis of novel 3‐(5‐amino‐[1,3,4]thiadiazol‐2‐yl)‐2__H__‐pyrano[2,3‐__c__]pyridine‐2‐ones was developed. In the first step, a new 2__H__‐pyrano[2,3‐__c__]pyridine‐3‐carboxamide **5** was prepared by Knoevenagel condensation of pyridoxal hydrochloride with cyano