Liquid-phase synthesis of 2-(alkylthio)
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Chih-Ming Yeh; Chung-Ming Sun
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Article
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1999
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Elsevier Science
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French
โ 244 KB
An efficient liquid-phase synthesis of 2-alkylthio-5-carbamoylbenzimidazoles 1 is described. Immobilized ofluoronitrobenzene 2 undergoes nucleophilic addition of primary amine to afford o-nitroaniline derivatives 3. Subsequent reduction of the aromatic nitro group followed by cyclization gives a PEG