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Synthesis of 2-[3′-(trifluoromethyl)anilino] -5-hydroxynicotinic acid

✍ Scribed by Josef Němec; Fred S. Meeker Jr.; Eric C. Schreiber


Book ID
112123227
Publisher
Journal of Heterocyclic Chemistry
Year
1974
Tongue
English
Weight
414 KB
Volume
11
Category
Article
ISSN
0022-152X

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Synthesis of 3-phenyl-5-(trifluoromethyl
✍ James W. Pavlik; Jennifer A. Lowell; Vuthichai Ervithayasuporn 📂 Article 📅 2005 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 65 KB

Reaction of 4,4,4-trifluoro-1-phenyl-1,3-butanedione with hydroxylamine led to the formation of 5hydroxy-3-phenyl-5-(trifluoromethyl)-4,5-dihydroisoxazole which was dehydrated to 3-phenyl-5-(trifluoromethyl)isoxazole. This isomer can also be synthesized by reaction of 4-chloro-4-phenyl-1,1,1-trifluo