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Synthesis of 2-(1-methyl-4-piperylid-3-ene)-9,10-dihydro-4H-benzo[4,5]- cyclohepta[1,2-b]thiophen-10-one, a new potential antiasthmatic analogue of zaditene

✍ Scribed by Michal W. Majchrzak


Book ID
112127970
Publisher
Journal of Heterocyclic Chemistry
Year
1985
Tongue
English
Weight
155 KB
Volume
22
Category
Article
ISSN
0022-152X

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## Abstract magnified image Reactions of 3‐chlorobenzo[__b__]thiophene‐2‐carbonyl chloride with 2‐alkyl‐2‐aminopropanamides have been used to prepare a series of carboxamides **1a‐d** (yields 61‐85%). The products were submitted to base‐catalysed ring closure reactions to give the corresponding 4,