Molecular imaging and quantification of myocardial b 1 -adrenoceptor (AR) rather than total b-AR density is of great clinical interest since cardiac biopsy studies suggest that myocardial b 1 -AR density is reduced in patients with chronic heart failure whereas cardiac b 2 -AR density may vary. Posi
β¦ LIBER β¦
Synthesis of [18F]FA-4 and [11C]pipzA-4 as radioligands for the high affinity choline uptake system
β Scribed by C. Gilissen; G. Bormans; T. de Groot; A. Verbruggen
- Book ID
- 101284997
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- French
- Weight
- 330 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0022-2135
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Arylboronic esters are readily converted to aryltrifluoroborates in the presence of aqueous fluoride. As such these represent attractive synthetic precursors that afford one-step labeling with [ 18 F]-fluoride for the generation of PET reagents. Herein we present the synthesis of a heretofore undisc