✦ LIBER ✦

Synthesis of [18F]-(S)-fluoxetine: A selective serotonine uptake inhibitor

✍ Scribed by Akli Hammadi; Christian Crouzel

Publisher: John Wiley and Sons
Year: 1993
Tongue: French
Weight: 328 KB
Volume: 33
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580330805

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✦ Synopsis

Abstract

The (S)‐N‐methyl‐γ‐[4‐(trifluoromethyl)phenoxy]benzenepropanamine, an antidepressant with potential applications in the treatment of other illnesses was labelled with fluorine‐18 for Positron Emission Tomography studies. The synthesis was accomplished from the [^18^F]‐4‐chlorobenzotrifluoride where [^18^F]‐(S)‐Fluoxetine was obtained with a radiochemical yield of 9–10% (decay corrected) and a specific radioactivity of 100–150 mCi/μmol (3.70–5.55 GBq/μmol) in a total synthesis time of 150 min. A facile isotopic exchange reaction was desmonstrated; it is expected to reduce the specific activity of the final [^18^F]‐product. The experimental parameters play an important role, which is discussed.

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