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Synthesis of 1,8- and 2,8-dihydrocycloheptapyrazol-8-one derivatives by the reactions of 3-acetyltropolone and its methyl ethers with phenylhydrazine

โœ Scribed by Kimiaki Imafuku; Akio Yamane; Hisashi Matsumura


Book ID
112126158
Publisher
Journal of Heterocyclic Chemistry
Year
1980
Tongue
English
Weight
300 KB
Volume
17
Category
Article
ISSN
0022-152X

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Enantioselective deprotonation of the 8-
โœ Daniele Simoni; Marinella Roberti; Riccardo Rondanin; Alan P. Kozikowski ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 213 KB

The enantioselective deprotonation of the 8-oxabicyclo[3.2. l]octan-3-one with chiral lithium amides 5 and 6, in the presence of LiC1, gave the chiral lithium enolates which were in turn reacted with methyl cyanoformate. The resulting chiral [3-keto esters were reduced with sodium amalgam to afford