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Synthesis of 17-deoxy-17.alpha.- and 17.beta.-20-pregnynes and -20-pregnenes

โœ Scribed by Krubiner, Alan M.; Gottfried, Norman; Oliveto, Eugene P.


Book ID
119956704
Publisher
American Chemical Society
Year
1969
Tongue
English
Weight
607 KB
Volume
34
Category
Article
ISSN
0022-3263

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In the search for potent inhibitors of P450 17, the key enzyme of androgen biosynthesis, the 20,21-aziridinyl- and 20-aminopregnene steroids 1-11 were synthesized and tested toward rat testicular P450 17. Only the aziridinyl-substituted pregnenolones (1 and 2) and progesterones (3 and 4), respective