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Synthesis of 1,5-disubstituted tetrazoles via Suzuki–Miyaura cross-coupling of 5-chloro-1-phenyltetrazole

✍ Scribed by Qing Tang; Ryan Gianatassio


Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
609 KB
Volume
51
Category
Article
ISSN
0040-4039

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Cross-coupling of 1-aryl-5-bromopyrazole
✍ Xiao-jun Wang; Jonathan Tan; Karl Grozinger 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 160 KB

The cross-coupling of 1-aryl-5-bromopyrazoles 4 with alkynes, vinyltins and arylboronic acids promoted by Pd(PPh 3 ) 4 aorded unsymmetrical 3,5-disubstituted 1-arylpyrazoles 5-8 in excellent yields. 1-Aryl-5bromopyrazoles 4 were prepared from their corresponding 1-arylpyrazolones 3 with PBr 3 in re¯