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Synthesis of 1,5-Disubstituted 1H-Tetrazole Derivatives via a Three-Component Reaction of Carbodiimides, Isocyanides, and Trimethylsilyl Azide

โœ Scribed by Ali Reza Kazemizadeh; Nasrin Hajaliakbari; Roghayeh Hajian; Nahid Shajari; Ali Ramazani


Book ID
112098238
Publisher
John Wiley and Sons
Year
2012
Tongue
German
Weight
142 KB
Volume
95
Category
Article
ISSN
0018-019X

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Copper-catalyzed synthesis of 5-substitu
โœ Tienan Jin; Fukuzou Kitahara; Shin Kamijo; Yoshinori Yamamoto ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 135 KB

The [3+2] cycloaddition between various nitriles and trimethylsilyl azide proceeds smoothly in the presence of a Cu I catalyst in DMF/ MeOH, to give the corresponding 5-substituted 1H-tetrazoles in good to high yields. The reaction most probably proceeds through the in situ formation of a copper azi