✦ LIBER ✦

Synthesis of 1,5-diaryl-3-methyl-1 H-pyrazolo[4,5-c]isoquinolines and studies of binding to specific peripheral benzodiazepine binding sites

✍ Scribed by Lucia Cecchi; Vittoria Colotta; Fabrizio Melani; Giovanna Palazzino; Guido Filacchioni; Claudia Martini; Gino Giannaccini; Antonio Lucacchini

Book ID: 102916159
Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 563 KB
Volume: 78
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600780602

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✦ Synopsis

Some 1,5-diaryl-3-methyl-1H-pyrazolo[4,5-c]isoquinolines were synthesized and tested for their ability to displace [3H]clonazepam or [3H]Ro 5-4864 from their specific binding on the central and peripheral benzodiazepine receptors. None of the tested compounds showed any activity as central binding inhibitors, while most of them were specific as peripheral binding inhibitors, although they were not very potent.

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