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Synthesis of [14C]boceprevir, [13C3]boceprevir, and [D9]boceprevir, a hepatitis C virus protease inhibitor

✍ Scribed by Sumei Ren; Pernilla Royster; Carolee Lavey; David Hesk; Paul McNamara; David Koharski; Van Truong; Scott Borges


Book ID
112132528
Publisher
John Wiley and Sons
Year
2012
Tongue
French
Weight
676 KB
Volume
55
Category
Article
ISSN
0022-2135

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Boceprevir is a hepatitis C virus (HCV) nonstructural protein (NS) 3/4A protease inhibitor that is currently being evaluated in combination with peginterferon alfa-2b and ribavirin in phase 3 studies. The clinical resistance profile of boceprevir is not characterized in detail so far. The NS3 protea