Synthesis of 14C-labelled dibenzo[d, g] [1,3,6]dioxazocine derivatives (EGYT-2474 and EGYT-2509)

✍ Scribed by E. Birkás-Faigl; J. Engler; G. Zólyomi; L. Rózsa

• Publisher: John Wiley and Sons
• Year: 1985
• Tongue: French
• Weight: 254 KB
• Volume: 22
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580221008

✦ Synopsis

Syn t h e e l s o f 2-chloro-12-( 3-dlmet h y l a a l n o p r o p y l )d i b e n z o [d,g] [ 1 , 3 . 6 ~d I o x a z o c i n e maleete ( EGYT-2474) end 2-chloro-12-(3-dlsethylamlno-2-methylpropyl)-dib e n r o [dog] fi.3.61 d l o x e t o c i n e h y d r o c h l o r i d e (EGM-2509) l a b e l l e d w i t h 14C-lsotope I s r e p o r t e d . The s y n t h e s l e o f above compounds wee based on [14C] methylene d l -I o d i d e which was p r e p a r e d b y t h e r e d u c t i o n o f [14C]lodofor~. [14C]Iodofor~ was s y n t h e s i s e d b y an l a p r o v e d method i n a r a d i o c h e a i c a l o v e r a l l y i e l d of 44% c a l c u l a t e d on barium [14C]carbonate.