Synthesis of 1,3,5-Triazabicyclo[3.1.0]hexanes Containing the Fragments of α-Amino Acids and Their Esters at the N(3) Atom.
✍ Scribed by A. V. Shevtsov; V. Yu. Petukhova; N. N. Makhova
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 72 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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📜 SIMILAR VOLUMES
N-Methyl b-amino acids are generally required for application in the synthesis of potentially bioactive modified peptides and other oligomers. Previous work highlighted the reductive cleavage of 1,3-oxazolidin-5-ones to synthesise N-methyl a-amino acids. Starting from a-amino acids, two approaches w
## Abstract 4‐(Dicyanomethylene)‐3‐methyl‐1‐phenyl‐2‐pyrazoline‐5‐one (1) readily reacts with α‐amino acids and their esters by Michael addition and subsequent elimination of HCN to the adducts 2a–k. One of these, 2i (obtained from methyl glycinate), adds stereoselectively to __N__‐phenylmaleimide