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Synthesis of 1,3-diazetidin-2-ones (aza-β-lactams) as rationally designed transpeptidase and β-lactamase inhibitors

✍ Scribed by A. Nangia; P.S. Chandrakala


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
263 KB
Volume
36
Category
Article
ISSN
0040-4039

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2-aryl-1,2-diazetidin-3-ones (aza-β-lact
✍ Joachim G. Schantl; Martin Decristoforo; John J. Daly 📂 Article 📅 1987 🏛 Elsevier Science 🌐 French ⚖ 267 KB

The a-(2\_arylhydrazino)-esters 1 react with i-propylmagnesium iodide to furnish 2-aryl-1,2-diazetidin-3-ones 2, which-in turn undergo ring-opening with methyllithium affording a-(2-arylhydrazino)-ketones 3. As part of a program to study a-(2-arylhydrazino)-alkanone arylhydrazonesl the synthesis of