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Synthesis of 12(R),13(S)-oxido-9z-octadecenoic (vernolic) and 13(S)-hydroxy-9z, 11E-octadecadienoic (coriolic) acids

✍ Scribed by Christine A. Moustakis; D.K. Weerasinghe; Paul Mosset; J.R. Falck; Charles Mioskowski

Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
126 KB
Volume
27
Category
Article
ISSN
0040-4039

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✦ Synopsis

Vernolic acid was prepared enantiospecifically from a readily available hydrate precursor and isomerized to (+)-coriolic acid using the methylmagnesium salt N-cyclohexylisopropylamine.

Recently, (-)-vernolic acid' ( ) and (+)-coriolic acid2'3 (6) have attracted carboof

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