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Synthesis of 1,2,5,6-/1,2,3,6-tetrahydropyridinyl-tetrahydro-cyclopentaisoxazole derivatives

✍ Scribed by Mija Ahn; Jung Mee Park; Ihl-Young Choi Lee; Myung Hee Jung


Publisher
Journal of Heterocyclic Chemistry
Year
2003
Tongue
English
Weight
59 KB
Volume
40
Category
Article
ISSN
0022-152X

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✦ Synopsis


Abstract

Fused tetrahydrocyclopenta‐isoxazoles were synthesized by 1,3‐dipolar cycloaddition reactions with pyridinealdoxime or tetrahydropyridinealdoxime and cycloalkenes.


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## Abstract The trimethylaluminum‐mediated Michael addition of ethyl phenyl‐H‐phosphinate to 1,2‐dihydrophosphinine oxides (**1A**) yielded 3‐(EtOPhP(O))‐1,2,3,6‐tetrahydrophosphinine oxides (**4**) in a selective manner, as a mixture of only two diastereomers. In the above type of reactions (e.g.,