Synthesis of 1,2,5,6-/1,2,3,6-tetrahydropyridinyl-tetrahydro-cyclopentaisoxazole derivatives
✍ Scribed by Mija Ahn; Jung Mee Park; Ihl-Young Choi Lee; Myung Hee Jung
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2003
- Tongue
- English
- Weight
- 59 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0022-152X
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Fused tetrahydrocyclopenta‐isoxazoles were synthesized by 1,3‐dipolar cycloaddition reactions with pyridinealdoxime or tetrahydropyridinealdoxime and cycloalkenes.
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## Abstract The trimethylaluminum‐mediated Michael addition of ethyl phenyl‐H‐phosphinate to 1,2‐dihydrophosphinine oxides (**1A**) yielded 3‐(EtOPhP(O))‐1,2,3,6‐tetrahydrophosphinine oxides (**4**) in a selective manner, as a mixture of only two diastereomers. In the above type of reactions (e.g.,