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Synthesis of 1,2,4-oxadiazines and their rearrangement to pyrimidines

✍ Scribed by Arthur A. Santilli; Anthony C. Scotese


Book ID
112125562
Publisher
Journal of Heterocyclic Chemistry
Year
1979
Tongue
English
Weight
258 KB
Volume
16
Category
Article
ISSN
0022-152X

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Synthesis of fluorinated 1,2,4-oxadiazin
✍ Antonio Palumbo Piccionello; Andrea Pace; Silvestre Buscemi; NicolΓ² Vivona; Gian πŸ“‚ Article πŸ“… 2009 πŸ› Elsevier Science 🌐 French βš– 336 KB

The reaction of 3-ethoxycarbonyl-5-perfluoroalkyl-1,2,4-oxadiazoles with hydroxylamines has been investigated, evidencing the possibility of competitive reaction paths. Nucleophilic addition of hydroxylamine to the electrophilic C(5) of the 1,2,4-oxadiazole ring, followed by ring-opening and ring-cl