Synthesis of fluorinated 1,2,4-oxadiazin
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Antonio Palumbo Piccionello; Andrea Pace; Silvestre Buscemi; NicolΓ² Vivona; Gian
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Article
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2009
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Elsevier Science
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French
β 336 KB
The reaction of 3-ethoxycarbonyl-5-perfluoroalkyl-1,2,4-oxadiazoles with hydroxylamines has been investigated, evidencing the possibility of competitive reaction paths. Nucleophilic addition of hydroxylamine to the electrophilic C(5) of the 1,2,4-oxadiazole ring, followed by ring-opening and ring-cl