✍ Scribed by S. S. Moerlein; K. K. Dalal; Y. Yano
No coin nor oath required. For personal study only.
The syntheres of two analogues of lowdensity lipoprotein (LDL) labelled with 123i Rabbit LDL was employed or l3'I was optimized for radbpharmaceutlcal application.
due to its uoefulness in pre-cliniml experimentation, although the parameters which were optlmlzed also pertain to human LDL. LDL was iodinated directly with exchange-labelled rpl]lCl to produce Injectable Val]LDL in 40% radiochemical yield within 30 min. A derlvatized version of LDL, ral]TC-LDL, radiochemical yield within 75 min by radioiodination of tyraminecellobiose (TC) via h . c & oxidation of 9followed by cross-linking to LDL using cyanuric chloride. Quality control tests Indicated that both radloiodinated LDL and TC-LDL were very similar in character to the native LDL molecule.
was produced In about 30% 0362-4803/87/111325-15W S O @ 1987 by John Wiley & Sons, Ltd.
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