Synthesis of 1,2-Disubstituted Carbocyclic Nucleoside Analogues of Cytidine

✍ Scribed by María José González-Moa; Pedro Besada; Carmen Terán; Lourdes Santana; Eugenio Uriarte; Dolores Viña

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: German
• Weight: 112 KB
• Volume: 89
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200690099

✦ Synopsis

Abstract

The synthesis of new 1,2‐disubstituted, five‐ or six‐ring‐carbocyclic nucleoside analogues of cytidine, compounds 1 and 2a–d, are described. These compounds were obtained by aminolysis, starting from the corresponding uracil derivative, via nucleophilic displacement of a triazolyl (Scheme 1) or a (2,4,6‐triisopropylphenyl)sulfonyl (TPS) group (Scheme 2) at 4‐position of the pyrimidine ring.