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Synthesis of 1,2-benzisothiazole derivatives and investigation of their putative histaminergic activity

✍ Scribed by Giovanni Morini; Cristina Pozzoli; Maristella Adami; Enzo Poli; Gabriella Coruzzi

Book ID
114019547
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
232 KB
Volume
54
Category
Article
ISSN
0014-827X

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## Abstract An improved and general synthesis of saccharin methylthio and methylsulfone derivatives from chlorosubstituted saccharins is presented. A large‐scale procedure for preparation of chloro‐substituted saccharins was developed. Treatment of the saccharin chlorides with sodium thiomethoxide