Synthesis of [119mSn]-mesoporphyrin IX dichloride

✍ Scribed by Jon F. Denissen

• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: French
• Weight: 282 KB
• Volume: 28
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580281210

✦ Synopsis

Abstract

Tin mesoporphyrin IX dichloride (Sn‐MPCl~2~) is a heme oxygenase inhibitor of current clinical interest for the treatment of neonatal hyperbilirubinemia. The synthesis of [^119m^Sn]‐MPCl~2~ for drug metabolism and disposition studies is reported. [^119m^Sn]‐MPCl~2~ was prepared in 60% radiochemical yield by metalation of the porphyrin nucleus of mesoporphyrin IX dihydrochloride with tin(II)‐119m acetate. The product had a specific activity of 43.4 mCi/mmol and a radiochemical purity of 99%, as determined by radio‐HPLC analysis.