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Synthesis of 10β-(1′-azirinyl)estr-4-en-3,17-dione as an aromatase inhibitor

✍ Scribed by Vincent C.O. Njar; Jörg Düerkop; Rolf W. Hartmann

Book ID
116066069
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
572 KB
Volume
61
Category
Article
ISSN
0039-128X

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✍ Jens Geisler; Arwed Cleve; Michael Harre 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 94 KB

AbstractÐAn ef®cient synthesis has been developed affording 11b-(4-aminophenyl)spiro[estr-4-ene-17b,2 H (5 H H)-furan]-3,5 H -dione (2), main metabolite of antiprogestin (Z)-11b-[4-(dimethylamino)phenyl]-17b-hydroxy-17a-(3-hydroxyprop-1-enyl)estr-4-en-3-one (1), in an overall yield of 21%.