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Synthesis of 1-methylpyrazolidine and some of its derivatives

โœ Scribed by Milton J. Kornet

Publisher
John Wiley and Sons
Year
1967
Tongue
English
Weight
413 KB
Volume
56
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

By MILTON J. KORNET

1-Methylpyrazolidine has been prepared via a two-step reaction sequence from ethyl acrylate and methylhydrazine, and also directly from trimethylene bromide and methylhydrazine. The N-methylpyrazolidino group was substituted for the dialkylamino group in a limited number of clinically effective agents. These derivatives are to be screened for pharmacologic activity.

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