Unambiguous synthesis of 1-methyl-3-hydr
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Diane Zimmermann; Povl Krogsgaard-Larsen; Jean-Daniel Ehrhardt; Ulf Madsen; Yves
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Article
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1998
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Elsevier Science
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French
โ 525 KB
2, oxazoles were used as intermediates in a new method for preparation of Nl-methyl-3-hydroxypyrazoles. Synthesis of this bicyclic system was achieved either by alkylation of 3-hydroxypyrazole with 1,2-dibromoethane or, with better yields, by cyclization of l-tosyl-2-(2-hydroxyethyl)pyrazol-3-ones