Synthesis of 1-hydroxy-3-isobutyl,-6-(1-hydroxy-1-methylethyl)-2-pyrazinone and the structure of muta-aspergillic acid

✍ Scribed by M. Sugiyama; M. Masaki; M. Ohta

• Book ID: 104213165
• Publisher: Elsevier Science
• Year: 1967
• Tongue: French
• Weight: 205 KB
• Volume: 8
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)71575-9

✦ Synopsis

In 1960 Nakamura isolated a new growth inhibitant against hiochibacteria from the culture filtrates of Asveraillus Orvzae as pale yellow needles and proposed to designate the antibiotic as muta-aspergillic acid (2). The acid is reduced with hydroiodic acid in phosphoric acid to yield deoxy-mutaaspergillic acid, which has been shown to be identical with the synthetic j-isobutyl-6-isopropyl-2-hydroxypyrasine (I) (3).