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Synthesis of 1-H-1,5-benzodiazepines derivatives using SiO2/ZnCl2

✍ Scribed by Raquel G. Jacob; Cátia S. Radatz; Mariele B. Rodrigues; Diego Alves; Gelson Perin; Eder J. Lenardão; Lucielli Savegnago

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
96 KB
Volume
22
Category
Article
ISSN
1042-7163

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✦ Synopsis

Abstract

A general and easy method for the synthesis of several 1‐H‐1,5‐benzodiazepines using SiO~2~/ZnCl~2~ under solvent‐free conditions is described. This efficient and improved method furnishes selectively and in good yields the corresponding 1‐H‐1,5‐benzodiazepines derivatives starting from o‐phenylenediamine and cyclic or acyclic ketones. The catalytic system was reused up four times, and the use of focused microwaves accelerates the reaction. © 2011 Wiley Periodicals, Inc. Heteroatom Chem 22:180–185, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.20674

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