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Synthesis of 1-Aza-cryptophycin 1, an Unstable Cryptophycin. An Unusual Skeletal Rearrangement

✍ Scribed by Russell A Barrow; Richard E Moore; Lian-Hai Li; Marcus A Tius

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
228 KB
Volume
56
Category
Article
ISSN
0040-4020

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✦ Synopsis

AbstractÐA total synthesis of cryptophycin 337 (1-aza-cryptophycin 1, 2), an analogue of the potent antitumor antibiotic cryptophycin 1 (1), is described. Cryptophycin 337 was unstable and underwent an unexpected skeletal rearrangement. (R)-Mandelic acid was used as the sole source of asymmetry for the synthesis of unit A.

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