Synthesis of 1-alkylthio-3H-indolizin-3-ones

✍ Scribed by B. A. Trofimov; L. N. Sobenina; A. I. Mikhaleva; M. P. Sergeeva; M. V. Sigalov; N. I. Golovanova

• Book ID: 104781815
• Publisher: Springer US
• Year: 1992
• Tongue: English
• Weight: 63 KB
• Volume: 28
• Category: Article
• ISSN: 0009-3122
• DOI: 10.1007/bf00474505

✦ Synopsis

We have recently tbund that 2-(t-alkylthio-2-cyanoethenyl)pyrroies are tbrmed in the reaction of ethyt pyrrole-2dithiocarboxylates of the I type with malonodinitrile and cyanoacetamide in the KOH--DMSO system with subsequent alkylation [1].

In attempting to extend this reaction to methylene-active compounds II with an ester grouping we observed that the principal (R = CH) or only pathway in this case is the formation of 1-ethylthio-3H-indolizin-3-ones IVa-c.