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Synthesis of 1-[2′,5′-dimethoxy-4′-(β-fluoroethyl)phenyl]-2-aminopropane:studies related to 18F-labeled serotonin receptor ligands

✍ Scribed by John M. Gerdes; Chester A. Mathis; Alexander T. Shulgin

Publisher: Elsevier Science
Year: 1988
Tongue: French
Weight: 261 KB
Volume: 29
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)82391-6

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✦ Synopsis

Synthesis of the titled 2,5-dimethoxy-4-fluoroalkylamphetamine is reported. The highly functionalized aromatic nucleus of the key fluorination precursor was utimately derived from a low temperature aromatic halogen-lithium exchange reaction followed by alkylation of the resultant anion with ethylene oxide.

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