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Synthesis of (1-13C)-1-deoxynojirimycin

✍ Scribed by A. Berger; M. Ebner; A.E. Stütz


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
119 KB
Volume
36
Category
Article
ISSN
0040-4039

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Asymmetric synthesis of (+)-1-deoxynojir
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An asymmetric synthesis of (+)-l-deoxynojirimycin (1) in 14 steps starting from diene ( 5) is described. The key transformations in the sequence are a Sharpless dihydroxylation and epoxidation followed by a regio-and stereoselective aminolysis of vinyl epoxide 11 to give piperidine 12.

The chemistry of the 1-deoxynojirimycin
✍ Horst Böshagen; Fred-Robert Heiker; A. Matthias Schüller 📂 Article 📅 1987 🏛 Elsevier Science 🌐 English ⚖ 569 KB

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