Synthesis of 0-(2-0-α-D-glucopyranosyl)-β-D-galactopyranoside of optically pure δ-hydroxyl-L-lysyl-glycine: a glycopeptide of the glomerular basement membrane

✍ Scribed by H.J. Koeners; Cecile Schattenkerk; J. Verhoeven; J.H. van Boom

• Book ID: 104225392
• Publisher: Elsevier Science
• Year: 1980
• Tongue: French
• Weight: 257 KB
• Volume: 21
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)92610-8

✦ Synopsis

The synthesis of the glycopeptide Glu-Gal-Hyl-Gly, which forms an essential part of the Glomerular Basement Membrane, is presented. The use of the levulinyl group as a protective group and the availability of the optically pure and fully-protected lactone of S-hydroxy-L-Lysine (Hyl) will be put forward.

The disaccharide 2-0-a-D-glucopyranosyl-D-galactopyranose which is linked via a S-glycosidic bond with the alcoholic function of 6-hydroxy-L-Lysyl residue (L-Hyl) is part of the