Synthesis of 4-aza analog of ramelteon:
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Tatsuki Koike; Yasutaka Hoashi; Takafumi Takai; Osamu Uchikawa
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Article
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2011
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Elsevier Science
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French
β 408 KB
Intramolecular Diels-Alder reaction Desilylation-cyclization a b s t r a c t The 4-aza analog of ramelteon (Γ)-1, a novel tricyclic 1,6,7,8-tetrahydro-2H-cyclopenta[d]furo[2,3-b]pyridine derivative, was synthesized via the intramolecular inverse electron demand Diels-Alder reaction followed by fluor