Synthesis, molecular characterisation, and in vivo study of platinum(IV) coordination compounds against B16 mouse melanoma tumours

✍ Scribed by Iwona Łakomska; Anna Kaźnica; Romana Joachimiak; Andrzej Marszałek; Jerzy Sitkowski; Lech Kozerski; Tomasz Drewa

• Book ID: 111491459
• Publisher: Versita
• Year: 2011
• Tongue: English
• Weight: 388 KB
• Volume: 65
• Category: Article
• ISSN: 0366-6352
• DOI: 10.2478/s11696-011-0019-0

✦ Synopsis

Abstract

A novel platinum(IV) coordination compound with 6-mercaptopurine (6-Hmp) has been synthesised and characterised by IR and NMR spectroscopy. Spectroscopic parameters indicate the presence of two chelate (S-6, N-7) monodeprotonated ligands and two chloride ions in the coordination sphere of [PtCl2(6-mp)2] · H2O (I). Two Pt(IV) coordination compounds, [PtCl2(6-mp)2] · H2O (I) and [PtCl4(dbtp)2] (II), were used in the in vivo test against B16 mouse melanoma tumours. Cytotoxic activity of compound II against the tumour cells was found to be high (LC10 = 2.6 μM, LC50 = 17.0 μM, LC90 = 58.0 μM) compared to that of cisplatin.