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Synthesis, microwave-promoted catalytic activity in Suzuki–Miyaura cross-coupling reactions and antimicrobial properties of novel benzimidazole salts bearing trimethylsilyl group

✍ Scribed by Ülkü Yılmaz; Hasan Küçükbay; Nihat Şireci; Mehmet Akkurt; Selami Günal; Rıza Durmaz; M. Nawaz Tahir

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
227 KB
Volume
25
Category
Article
ISSN
0268-2605

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✦ Synopsis

A mixture of benzimidazole salts (2-7), Pd(OAc) 2 and K 2 CO 3 in DMF-H 2 O catalyzes the Suzuki-Miyaura cross-coupling reactions promoted by microwave irradiation resulting in high yield within a short time. In particular, the yield of the Suzuki-Miyaura reactions with aryl bromides was found to be nearly quantitative. The synthesized benzimidazole salts (2-7) were identified by 1 H-13 C, NMR, IR spectroscopic methods and microanalysis. The molecular structure of 1 was determined by X-ray crystallography. The antibacterial and antifungal activities of the novel benzimidazole derivatives (1-7) were also tested against standard strains.

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