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Synthesis, Incorporation into Triplex-Forming Oligonucleotide, and Binding Properties of a Novel 2‘-Deoxy- C -Nucleoside Featuring a 6-(Thiazolyl-5)benzimidazole Nucleobase

✍ Scribed by Guianvarc'h, Dominique; Fourrey, Jean-Louis; Maurisse, Rosalie; Sun, Jian-Sheng; Benhida, Rachid


Book ID
125893495
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
160 KB
Volume
4
Category
Article
ISSN
1523-7060

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The synthesis of a new ribonucleoside analogue, which combines two modifications, namely a 2%-aminoethoxy side-chain on the ribose and a 5-methyl-1H-pyrimidin-2-one ( 4H T) unit as a base replacement, is presented. This building block was incorporated into triplex forming oligonucleotides and the bi