Synthesis in the Sex Hormone Group
β Scribed by COHEN, A.
- Book ID
- 109513222
- Publisher
- Nature Publishing Group
- Year
- 1935
- Tongue
- English
- Weight
- 211 KB
- Volume
- 136
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/136869a0
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
dfter hiving tliscttsscd iii tlie jircccdiiig lectures the inotlificat,ion of the sterol iiiiclclts in tllc hilt\* iicids, iicutriil sapotiiiis, carrliric poisons, :ind vitiitiiiiis, let 11s turn to n cotisidcration of the Iiist Iiirpc group, t81ic discovery of which pl:ic~d tlic iliiportiilicc of t
The water mold sex hormone oogoniol (la) has been synthesized from adrenosterone in 18 steps in 7.0% overall yield. The crucial step introduces the stereochemistry at C-15 and C-20 through a highly efficient 1,4-addition of the organocyanocuprate generated from the side chain Grignard reagent (fi) a