Synthesis in E. coli of α1-antitrypsin variants of therapeutic potential for emphysema and thrombosis

Biochemical intermediates in α1-antitryp

Biochemical intermediates in α1-antitrypsin deficiency: Residual family resemblance for total α1-antitrypsin, oxidized α1-antitrypsin, and immunoglobulin E after adjustment for the effect of the Pi locus

✍ E. K. Silverman; M. A. Province; E. J. Campbell; J. A. Pierce; D. C. Rao; N. G. 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 812 KB

## Louis a,-antitrypsin (a1 AT) deficiency is variably associated with the development of pulmonary emphysema. To gain insight into the process which begins the Z point mutation at the Protease Inhibitor (Pi) locus and results in the variable development of emphysema, three quantitative phenotypes