Synthesis, Crystal Structure, Spectroscopic, Electrochemical and Antimicrobial Properties of Cu(II) Complex with the Mixed Ligands of 2,9-Dimethyl-1,10-phenanthroline and 4-Hydroxypyridine-2,6-dicarboxylic Acid

✍ Scribed by Zohreh Derikvand; Gholam Reza Talei; Hossein Aghabozorg; Marilyn M. Olmstead; Azadeh Azadbakht; Andya Nemati; Jafar Attar Gharamaleki

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 86 KB
• Volume: 28
• Category: Article
• ISSN: 0256-7660
• DOI: 10.1002/cjoc.201090358

✦ Synopsis

Abstract

A mononuclear Cu(II) complex with mixed ligands, formulated as [Cu(hypydc)(dmp)]·H~2~O (hypydc=4‐hydroxypyridine‐2,6‐dicarboxylate, dmp=2,9‐dimethyl‐1,10‐phenanthroline), was synthesized and well characterized by single crystal X‐ray diffraction analysis, as well as spectroscopic (IR, UV‐Vis), and electrochemical methods. The Cu(II) atom exhibits a distorted square‐pyramidal geometry. Intermolecular OH···O and CH···O hydrogen bonds, π‐π stacking interactions and CH···π interactions seem to be effective in the stabilization of the crystal structure. The complex was also evaluated for its antimicrobial activity using in vitro microdilution methods. Six standard bacteria and a strain of Candida albicans were used for the antimicrobial activities. There was a very strong activity against Candida albicans and significant activities against Enterococcus fecalis, Listeria monocytogenes, Bacillus cereus and Staphylococcus aureus, indicating important biological activities of the complex.