Synthesis, Conformation, and Metabolism of a Selenium Bilirubin
โ Scribed by Brahmananda Ghosh; David A. Lightner; Antony F. McDonagh
- Publisher
- Springer Vienna
- Year
- 2004
- Tongue
- English
- Weight
- 374 KB
- Volume
- 135
- Category
- Article
- ISSN
- 0026-9247
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๐ SIMILAR VOLUMES
Optically active, diastereomeric synthetic bitirubin analogs (1 and 2) with an e~-methyl and a ยข3-methyl in each propionic acid side chain were synthesized. Both diastereomers adopt a folded, ridge-tile conformation. The methyls force the pigment to adopt either a left-handed (M) or right-handed (P)
&,cr'R)-Mesobilirubin-XIIIa, a tetrapyrrole dicarboxylic acid with P-helicity conformation stabilized by intramolecular hydrogen bonding, exhibits intense bisignate circular dichroism in CHCl, (A&t +246, A,398 -133) and many other solvents, except in (CH,),SO, where the intensity drops lo-fold (EEx