Synthesis, conformation, and membrane modifying properties of the trikoningin KB lipopeptaibols: Effect of hydrophobicity and chirality in position 1

Total synthesis and membrane modifying p

Total synthesis and membrane modifying properties of the lipopeptaibol trikoningin KB II and its analogues with acyl chains of different length at the N- and C-termini

✍ Claudia Piazza; Fernando Formaggio; Marco Crisma; Claudio Toniolo; Johan Kamphui 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 95 KB 👁 2 views

Trikoningin KB II, a ten-amino acid residue lipopeptaibol blocked at the N-terminus by the n-octanoyl group and at the C-terminus by the 1,2-amino alcohol L-leucinol, and extracted from the fungus Trichoderma koningii, exhibits membrane-modifying properties. We have synthesized by solution-phase met