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Synthesis, conformation and biological activity of centrally modified pseudopeptidic analogues of For-Met-Leu-Phe-OMe

✍ Scribed by C. Giordano; G. Lucente; A. Masi; M. Paglialunga Paradisi; A. Sansone; S. Spisani

Publisher
Springer
Year
2006
Tongue
English
Weight
343 KB
Volume
33
Category
Article
ISSN
0939-4451

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The Importance of the Methionine Configu
The Importance of the Methionine Configuration in for-Met-Leu-Phe-OMe Biological Activities
✍ Susanna Spisani; Giorgio Cavicchioni πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 English βš– 64 KB

for-D-Met-L-Leu-L-Phe-OMe was synthesized in order to understand the importance of the methionine configuration on human neutrophil biological activity. Our results show that both chemotactic response and lysozyme release are lower than those of the parent fMLP-OMe, indicating that the specific rece