Synthesis, complexation, and biological activity studies of 4-aminomethyl-7,8-dihydroxy coumarines and their crown ether derivatives

✍ Scribed by Arzu Gümüş; Şeref Karadeniz; Halil İbrahim Uğraş; Mustafa Bulut; Ümit Çakır; Ahmet Ceyhan Gören

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2010
• Tongue: English
• Weight: 176 KB
• Volume: 47
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.435

✦ Synopsis

Abstract

magnified image The article focuses synthesis of novel 4‐aminomethyl‐7,8‐dihydroxy coumarins and their crown ether derivatives. The purified novel coumarins and their crown ether derivatives were identified by ^1^H NMR, ^13^C NMR, mass spectrometry and elemental analysis. The 1:1 binding constants of Ca^2+^, Mg^2+^, Fe^2+^, Zn^2+^, Ni^2+^, Cd^2+^, Co^2+^, and Mn^2+^ ions at 25°C ± 0.1 with the 4‐aminomethyl‐7,8‐dihydroxy coumarins and their crown ether derivatives estimated using extraction procedure with Inductively Coupled Plasma‐Atomic Emission Spectroscopy in dichloromethane/water membrane systems. Synthesized compounds were investigated for complexation and biological activity properties. Best results in biological activity studies were observed for antioxidant activity. J. Heterocyclic Chem., (2010).